Panadrex Pure 500 mg 48 Tabs

Panadrex PURE contains Paracetamol which belongs to a group of medicines called analgesics and antipyretics. The mechanism of action is probably similar to that of aspirin and dependent on the selective inhibition of prostaglandin synthesis.

Indications:
* Mild to moderate pain associated with toothache, headache, earache, backache, sore throat, dysmenorrhea, migraine, neuralgia, rheumatic aches and teething pain.
* Fever associated with influenza, bacterial infections, inflammations, colds and childhood infections like chickenpox, measles, mumps and reactions to vaccinations.

Posology:
* Adults and children ≥ 16 years: 1-2 tablets every 4-6 hours (Do not exceed 8 tablets in 24 hours)
* Children 10-15 years: 1 tablet every 4-6 hours (Do not exceed 4 tablets in 24 hours)

Precautions:
• Do not exceed the stated dose.
• Do not take more frequently than every 4 hours.
• Used with caution in patients with severe kidney or liver problems, alcoholic liver disease, and glutathione depleted states
• Paracetamol overdose may cause liver failure. 
• Patients should follow the advice of their doctor regarding its use in pregnancy. Available published data does not contraindicate breastfeeding.

Contraindications:
* Hypersensitivity to the active substance or any of the excipients.
• If patient takes other paracetamol-containing medications

Undesirable effects:
Side effects of paracetamol are rare and usually mild, though hematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Skin rash and other hypersensitivity reactions occur occasionally.

Pharmacokinetic properties:
• Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. The concentration in plasma reaches a peak in 30 to 60 minutes and the plasma half-life is 1 – 4 hours after therapeutic doses.
• Paracetamol is relatively uniformly distributed throughout most body fluids. Plasma protein binding is variable; 20 to 30% may be bound at the concentrations encountered during acute intoxication.
• Paracetamol is metabolized in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates, with about 10% as glutathione conjugates. Less than 5% is excreted as unchanged paracetamol.

Storage:
• Keep in a safe place, out of the reach and sight of children.
• Store at temperature not exceeding 25° C, Protect from light.

How to use? 

Adults and children ≥ 16 years: 1-2 tablets every 4-6 hours (Do not exceed 8 tablets in 24 hours)
Children 10-15 years: 1 tablet every 4-6 hours (Do not exceed 4 tablets in 24 hours)